ACVR2B Effector Reporter Cell
CBP74280
| I. Background | |
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激活素 A（Activin A）是轉(zhuǎn)化生長因子-β（TGF-β）超家族的重要成員，是一種多能因 子，參與過敏、自身免疫性疾病、癌癥等免疫失調(diào)疾病的發(fā)生。 |
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| II. Description | |
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ACVR2B Effector Reporter Cell 報告基因藥靶模型很好的模擬了體內(nèi) ACVR2A 的信號轉(zhuǎn)導過程，原理見圖 所示。
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| III. Introduction | |
| Expressed gene: | ACVR2B |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+ 200 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 2. ACVR2B Effector Reporter Cell 測序結(jié)果 ACVR2A(NM_001616.5): c.409_410insT/ ACVR2A:p.Y137Lfs*76  Figure 3. Dose Response of Recombinant Human Activin A in ACVR2B Effector Cell(2C8).Dose Response of Recombinant Human GDF-8 in ACVR2B Effector Reporter Cell(2C8).Dose Response of Recombinant Human GDF-11 in ACVR2B Effector Reporter Cell (2C8). |
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Figure 4. Inhibition of Human GDF-8 induced Reporter Activity byACVR2 Blocking Ab in ACVR2B Effector Reporter Cell(2C8). Inhibition of Human GDF-11 induced Reporter Activity by ACVR2 Blocking Ab in ACVR2B Effector Reporter Cell(2C8).
Figure 5. Inhibition of Recombinant Human Activin A-induced Reporter Activity by Samples in ACVR2B Effector Reporter Cell (2C8).
